Senior Scientist (all gender), LG-2019-5b

The RCI - Regensburg Center for Interventional Immunology (foundation under public law) is a novel biomedical research center focusing on translational immunology in the fields of cancer immunotherapy, transplant rejection and autoimmunity. The objective of the RCI is to develop effective immune therapeutic strategies in these areas.

The Chair for Functional Immune Cell Modulation at RCI, Prof. Dr. Luca Gattinoni is recruiting a

Senior Scientist (all gender), reference number LG-2019-5b

with proved experience in the field of human T cell immunobiology and T cellengineering. The position is initially limited to three years with the possibility to be continued and is remunerated on the TV-L salary scale (TV-L EG 14).

The senior scientist will be responsible for the development of clinical-grade protocols for the manufacturing of gene-engineered T cells that will be employed in Phase 1/2 clinical studies at the University Hospital Regensburg. Projects derive from recent basic research and translational pre-clinical studies conducted at the RCI and primarily within the Department of Functional Immune Cell Modulation. Gene manipulations encompass the modulation of transcription factors, microRNAs and metabolic checkpoints coupled with CAR and TCR platforms to functionally improve the antitumor efficacy of generedirected T cells.

Responsibilities include, but are not limited to:

  • Perform all tasks associated with the manufacturing of clinical-grade cell products including the development of standard operating procedures (SOPs), batch records and other GMP documentation.
  • Design and conduct clinical assays required to support assessment of T cell therapies.
  • Successfully troubleshoot processing and equipment issues.

The ideal candidate possesses:

  • PhD in Molecular Biology, Cell Biology, Immunology or a relevant discipline and 5 or more years of cGMP experience in a T cell manufacturing and biotechnology environment.
  • Extensive experience in isolating, culturing human T cells.
  • Extensive experience with virus-based and nonviral gene delivery platforms.
  • Experience with automated processing equipment.
  • Strong knowledge of cGMP regulations and experience in writing SOPs and documentation associated with clinical-grade cell manufacturing.
  • Excellent communications skills, both oral and written in English.
  • Strong analytical, organizational and time management skills.

The RCI follows the goal of professional equality for all genders and therefore strongly encourages qualified women to apply. In addition, the RCI supports work-family balance.

The RCI is an equal opportunity employer and candidates with disabilities will be given preference, provided they are equally qualified.

If we have awakened your interest and you are open to new professional challenges, we would be delighted to receive an informative application from you.

Please send your full application including a statement of interest, curriculum vitae, certificates, expected availability date, a list of publications and 2-3 references by e-mail to Prof. Dr. Luca Gattinoni (bewerbungen.rci@ukr.de). Application deadline is June 30, 2020.

RCI – Regensburger Centrum für Interventionelle Immunologie
Franz-Josef-Strauss-Allee 11
93053 Regensburg
Germany

For more information contact Prof. Dr. Luca Gattinoni (e-mail: luca.gattinoni@ukr.de; phone: +49 941 944 38132).

www.rcii.de

Post-doctoral Fellow in “Functions of T cells in tissues” (all gender, reference number MF-2020-1)

The RCI - Regensburg Center for Interventional Immunology (foundation under public law) is a novel biomedical research center focusing on translational immunology in the fields of cancer immunotherapy, transplant rejection and autoimmunity. The objective of the RCI is to develop effective immune therapeutic strategies in these areas.

The Chair for Immunology at the RCI, Prof. Dr. Markus Feuerer is recruiting a

Post-doctoral Fellow in “Functions of T cells in tissues” (all gender, reference number MF-2020-1)

with a track record in the field of T cell biology, with substantial experience working with regulatory T cells or T cells in tissues. The position is initially limited to three years and is remunerated on the TV-L salary scale (TV-L EG 13).

The Chair for Immunology investigates mechanisms underlying the complex interplay of immune cell regulation. Regulatory T cells (Treg) are critical to maintain self-tolerance. They modulate the functions of different immune cells, thereby affecting a variety of conditions, including autoimmunity, cancer, allergy and inflammation. In addition, it is becoming increasingly clear that specialized Treg cells in tissues are important to support organ homeostasis and tissue regeneration, with yet not well-understood mechanisms. We offer a postdoctoral position to study the functions of Treg cells and other T cells in tissues1-5.

Responsibilities include, but are not limited to:

  • Design and conduct research projects understanding the communication between T cells and tissue cells (in vitro and in vivo)
  • Establishing activities to systematically target interactions between T cells and non-immune cell
  • Writing/publishing scientific manuscripts
  • Presentation of data on international meetings

Requirement:
We are looking for a highly motivated and enthusiastic individual, able to work independently as well as a part of an interdisciplinary team

  • PhD or equivalent in life sciences, with a strong background in cell and molecular biology
  • Background in T cell immunology, substantial experience working with regulatory T cells or T cells in tissues
  • Experience with in vivo model systems
  • Strong record of publications in peer reviewed journals
  • Excellent communication skills and proficiency in English are mandatory

We offer:
We offer the opportunity to work at the interface of the adaptive immune system and the tissue environment, which is one of the most exciting emerging fields in immunology, with implications for cancer, autoimmunity, chronic inflammation and tissue regeneration. We provide cutting-edge technologies, including epigenetic analysis of immune cells and next-generation single cell sequencing techniques (sc-RNA-seq and sc-ATAC-seq).

The RCI follows the goal of professional equality for all genders and therefore strongly encourages qualified women to apply. In addition, the RCI supports work-family balance.

The RCI is an equal opportunity employer and candidates with disabilities will be given preference, provided they are equally qualified.

If we have awakened your interest and you are open to new professional challenges, we would be delighted to receive an informative application from you.  

Please send your full application including a statement of interest, curriculum vitae, certificates, expected availability date, a list of publications and 2-3 references by e-mail to Prof. Dr. Markus Feuerer (bewerbungen.rci@ukr.de). Application deadline is June 19th, 2020.

RCI – Regensburg Center for Interventional Immunology
Franz-Josef-Strauss-Allee 11
93053 Regensburg
Germany
 
For more information please contact Prof. Dr. Markus Feuerer(e-mail: markus.feuerer@ukr.de; phone: +49 941 944 38121).

www.rcii.de
Project related References:

  1. Delacher M, Imbusch CD, Hotz-Wagenblatt A, …. and Feuerer M. (2020). Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. Immunity, 18;52 (2):295-312
  2. Delacher M, Schmidl C, Herzig Y, …… and Feuerer M. (2019). Rbpj expression in regulatory T cells is critical for restraining TH2 responses. Nature Communications. 8;10(1):1621.
  3. Delacher M, Imbusch CD, Weichenhan D, …. and Feuerer M. (2017). Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nature Immunology; 18(10):1160-1172
  4. Richards DM, Kyewski B, Feuerer M. (2016). Re-examining the nature and function of self-reactive T cells. Trends in Immunology; 37(2):114-125.
  5. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, Lee J, Goldfine AB, Benoist C, Shoelson S, Mathis D. (2009). Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nature Medicine; 15(8):930-9.

 

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