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- Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T., Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages., Nat Immunol. 2018 Dec; 19(12):1319-1329. doi: 10.1038/s41590-018-0226-8.
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- Edinger M, Hoffmann P., Thymus-derived CD4+CD25+ FOXP3+ regulatory T cells in GVHD. In: Immune Biology of Allogeneic Hematopoietic Stem Cell Transplantation. 2nd Edition. Models in Discovery and Translation. Editors: Gerard Socie, Robert Zeiser, Bruce R. Blazar. Academic Press. Published Date: 6th December 2018.
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- Sterman J, Probst K, von Bomhard I, Etich J, Pitzler L, Niehoff A, Xu HC, Lang PA, Chmielewski M, Abken H, Blissenbach B, Machova A, Papadopoulou N, Brachvogel B., Depletion of collagen IX alpha1 impairs myeloid cell function., Stem Cells. 2018 Nov; 36(11):1752-1763. doi: 10.1002/stem.2892.
- Klobuch S, Steinberg T, Bruni E, Mirbeth C, Heilmeier B, Ghibelli L, Herr W, Reichle A, Thomas S., Biomodulatory Treatment With Azacitidine, All-trans Retinoic Acid and Pioglitazone Induces Differentiation of Primary AML Blasts Into Neutrophil Like Cells Capable of ROS Production and Phagocytosis., Front Pharmacol. 2018 Nov 27; 9:1380. doi: 10.3389/fphar.2018.01380.
- Brummer C, Faerber S, Bruss C, Blank C, Lacroix R, Haferkamp S, Herr W, Kreutz M, Renner K., Metabolic targeting synergizes with MAPK inhibition and delays drug resistance in melanoma., Cancer Lett. 2018 Nov 24; 442:453-463. doi: 10.1016/j.canlet.2018.11.018. Cancer Lett. 2018 Nov 24; 442:453-463.
- Renner K, Seilbeck A, Kauer N, Ugele I, Siska PJ, Brummer C, Bruss C, Decking SM, Fante M, Schmidt A, Hammon K, Singer K, Klobuch S, Thomas S, Gottfried E, Peter K, Kreutz M., Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells., Front Pharmacol. 2018 Nov 2; 9:1258. doi: 10.3389/fphar.2018.01258.
- Ždralević M, Brand A, Di Ianni L, Dettmer K, Reinders J, Singer K, Peter K, Schnell A, Bruss C, Decking SM, Koehl G, Felipe-Abrio B, Durivault J, Bayer P, Evangelista M, O'Brien T, Oefner PJ, Renner K, Pouysségur J, Kreutz M., Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism., J Biol Chem. 2018 Oct 12; 293(41):15947-15961. doi: 10.1074/jbc.RA118.004180.
- Di Liberto G, Pantelyushin S, Kreutzfeldt M, Page N, Musardo S, Coras R, Steinbach K, Vincenti I, Klimek B, Lingner T, Salinas G, Lin-Marq N, Staszewski O, Costa Jordao MJ, Wagner I, Egervari K, Mack M, Bellone C, Blumcke I, Prinz M, Pinschewer DD, Merkler D., Neurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping., Cell. 2018 Oct 4; 175(2):458-471.e19. doi: 10.1016/j.cell.2018.07.049.
- Lacroix R, Rozeman EA, Kreutz M, Renner K, Blank CU., Targeting tumor-associated acidity in cancer immunotherapy., Cancer Immunol Immunother. 2018 Sep; 67(9):1331-1348. doi: 10.1007/s00262-018-2195-z. Review
- Schmidl C, Delacher M, Huehn J, Feuerer M., Epigenetic mechanisms regulating T-cell responses., J Allergy Clin Immunol. 2018 Sep; 142(3):728-743. doi: 10.1016/j.jaci.2018.07.014. Review
- Quandt J, Schlude C, Bartoschek M, Will R, Cid-Arregui A, Schölch S, Reissfelder C, Weitz J, Schneider M, Wiemann S, Momburg F, Beckhove P., Long-peptide vaccination with driver gene mutations in p53 and Kras induces cancer mutation-specific effector as well as regulatory T cell responses., Oncoimmunology. 2018 Sep 21; 7(12):e1500671. doi: 10.1080/2162402X.2018.1500671.
- Yamauchi Y, Safi S, Blattner C, Rathinasamy A, Umansky L, Juenger S, Warth A, Eichhorn M, Muley T, Herth FJF, Dienemann H, Platten M, Beckhove P, Utikal J, Hoffmann H, Umansky V., Circulating and Tumor Myeloid-derived Suppressor Cells in Resectable Non-Small Cell Lung Cancer., Am J Respir Crit Care Med. 2018 Sep 15; 198(6):777-787. doi: 10.1164/rccm.201708-1707OC.
- Golumba-Nagy V, Kuehle J, Hombach AA, Abken H., CD28-ζ CAR T Cells Resist TGF-β Repression through IL-2 Signaling, Which Can Be Mimicked by an Engineered IL-7 Autocrine Loop., Mol Ther. 2018 Sep 5; 26(9):2218-2230. doi: 10.1016/j.ymthe.2018.07.005.
- Gerthofer V, Kreutz M, Renner K, Jachnik B, Dettmer K, Oefner P, Riemenschneider MJ, Proescholdt M, Vollmann-Zwerenz A, Hau P, Seliger C., Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma., Int J Mol Sci. 2018 Aug 31; 19(9). pii: E2586. doi: 10.3390/ijms19092586.
- Singer K, Cheng WC, Kreutz M, Ho PC, Siska PJ., Immunometabolism in cancer at a glance., Dis Model Mech. 2018 Aug 2; 11(8). pii: dmm034272. doi: 10.1242/dmm.034272. Review.
- Wolff D, Greinix H, Lee SJ, Gooley T, Paczesny S, Pavletic S, Hakim F, Malard F, Jagasia M, Lawitschka A, Hansen JA, Pulanic D, Holler E, Dickinson A, Weissinger E, Edinger M, Sarantopoulos S, Schultz KR., Biomarkers in chronic graft-versus-host disease: quo vadis?., Bone Marrow Transplant. 2018 Jul; 53(7):832-837. doi: 10.1038/s41409-018-0092-x.
- Riquelme P, Haarer J, Kammler A, Walter L, Tomiuk S, Ahrens N, Wege AK, Goecze I, Zecher D, Banas B, Spang R, Fändrich F, Lutz MB, Sawitzki B, Schlitt HJ, Ochando J, Geissler EK, Hutchinson JA., TIGIT+ iTregs elicited by human regulatory macrophages control T cell immunity., Nat Commun. 2018 Jul 20; 9(1):2858. doi: 10.1038/s41467-018-05167-8.
- Kiener R, Fleischmann M, Wiegand MA, Lemmermann NAW, Schwegler C, Kaufmann C, Renzaho A, Thomas S, Felder E, Niller HH, Asbach B, Wagner R., Efficient Delivery of Human Cytomegalovirus T Cell Antigens by Attenuated Sendai Virus Vectors., J Virol. 2018 Jul 17; 92(15). pii: e00569-18. doi: 10.1128/JVI.00569-18.
- Dettling S, Stamova S, Warta R, Schnölzer M, Rapp C, Rathinasamy A, Reuss D, Pocha K, Roesch S, Jungk C, Warnken U, Eckstein V, Grabe N, Schramm C, Weigand MA, von Deimling A, Unterberg A, Beckhove P*, Herold-Mende C*., Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma., Clin Cancer Res. 2018 Jun 15; 24(12):2951-2962. doi: 10.1158/1078-0432.CCR-17-1839.
- Doebbeler M, Koenig C, Krzyzak L, Seitz C, Wild A, Ulas T, Baßler K, Kopelyanskiy D, Butterhof A, Kuhnt C, Kreiser S, Stich L, Zinser E, Knippertz I, Wirtz S, Riegel C, Hoffmann P, Edinger M, Nitschke L, Winkler T, Schultze JL, Steinkasserer A, Lechmann M., CD83 expression is essential for Treg cell differentiation and stability., JCI Insight. 2018 Jun 7; 3(11). pii: 99712. doi: 10.1172/jci.insight.99712.
- Jetani H, Garcia-Cadenas I, Nerreter T, Thomas S, Rydzek J, Meijide JB, Bonig H, Herr W, Sierra J, Einsele H, Hudecek M., CAR T-cells targeting FLT3 have potent activity against FLT3-ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib., Leukemia. 2018 May; 32(5):1168-1179. doi: 10.1038/s41375-018-0009-0.
- Vatter S, Schmid M, Gebhard C, Mirbeth C, Klobuch S, Rehli M, Herr W, Thomas S., In-vitro blockade of the CD4 receptor co-signal in antigen-specific T-cell stimulation cultures induces the outgrowth of potent CD4 independent T-cell effectors., J Immunol Methods. 2018 Mar; 454:80-85. doi: 10.1016/j.jim.2017.11.006.
- Ulmer A, Dietz K, Werner-Klein M, Häfner HM, Schulz C, Renner P, Weber F, Breuninger H, Röcken M, Garbe C, Fierlbeck G, Klein CA., The sentinel lymph node spread determines quantitatively melanoma seeding to non-sentinel lymph nodes and survival., Eur J Cancer. 2018 Mar; 91:1-10. doi: 10.1016/j.ejca.2017.12.002.
- Böttcher M, Renner K, Berger R, Mentz K, Thomas S, Cardenas-Conejo ZE, Dettmer K, Oefner PJ, Mackensen A, Kreutz M, Mougiakakos D., D-2-hydroxyglutarate interferes with HIF-1α stability skewing T-cell metabolism towards oxidative phosphorylation and impairing Th17 polarization., Oncoimmunology. 2018 Mar 26; 7(7):e1445454. doi: 10.1080/2162402X.2018.1445454.
- Ghimire S, Matos C, Caioni M, Weber D, Peter K, Holler E, Kreutz M, Renner K., Indoxyl 3-sulfate inhibits maturation and activation of human monocyte-derived dendritic cells., Immunobiology. 2018 Feb; 223(2):239-245. doi: 10.1016/j.imbio.2017.10.014.
- Ullrich E, Abendroth B, Rothamer J, Huber C, Büttner-Herold M, Buchele V, Vogler T, Longerich T, Zundler S, Völkl S, Beilhack A, Rose-John S, Wirtz S, Weber GF, Ghimire S, Kreutz M, Holler E, Mackensen A, Neurath MF, Hildner K., BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease., J Clin Invest. 2018 Mar 1; 128(3):916-930. doi: 10.1172/JCI89242.
- Haag GM, Zoernig I, Hassel JC, Halama N, Dick J, Lang N, Podola L, Funk J, Ziegelmeier C, Juenger S, Bucur M, Umansky L, Falk CS, Freitag A, Karapanagiotou-Schenkel I, Beckhove P, Enk A, Jaeger D., Phase II trial of ipilimumab in melanoma patients with preexisting humoural immune response to NY-ESO-1., Eur J Cancer. 2018 Feb; 90:122-129. doi: 10.1016/j.ejca.2017.12.001.
- Zimara N, Chanyalew M, Aseffa A, van Zandbergen G, Lepenies B, Schmid M, Weiss R, Rascle A, Wege AK, Jantsch J, Schatz V, Brown GD, Ritter U., Dectin-1 Positive Dendritic Cells Expand after Infection with Leishmania major Parasites and Represent Promising Targets for Vaccine Development., Front Immunol. 2018 Feb 26; 9:263. doi: 10.3389/fimmu.2018.00263.
- Schnell A, Schmidl C, Herr W, Siska PJ., The Peripheral and Intratumoral Immune Cell Landscape in Cancer Patients: A Proxy for Tumor Biology and a Tool for Outcome Prediction., Biomedicines. 2018 Feb 24; 6(1). pii: E25. doi: 10.3390/biomedicines6010025. Review
- Yu Y, Schleich K, Yue B, Ji S, Lohneis P, Kemper K, Silvis MR, Qutob N, van Rooijen E, Werner-Klein M, Li L, Dhawan D, Meierjohann S, Reimann M, Elkahloun A, Treitschke S, Dörken B, Speck C, Mallette FA, Zon LI, Holmen SL, Peeper DS, Samuels Y, Schmitt CA, Lee S., Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma., Cancer Cell. 2018 Feb 12; 33(2):322-336.e8.
- Werner-Klein M, Scheitler S, Hoffmann M, Hodak I, Dietz K, Lehnert P, Naimer V, Polzer B, Treitschke S, Werno C, Markiewicz A, Weidele K, Czyz Z, Hohenleutner U, Hafner C, Haferkamp S, Berneburg M, Rümmele P, Ulmer A, Klein CA., Genetic alterations driving metastatic colony formation are acquired outside of the primary tumour in melanoma., Nat Commun. 2018 Feb 9; 9(1):595. doi: 10.1038/s41467-017-02674-y.
- Hutchinson JA, Weigand K, Adenugba A, Kronenberg K, Haarer J, Zeman F, Riquelme P, Hornung M, Ahrens N, Schlitt HJ, Geissler EK, Werner JM., Predicting Early Viral Control under Direct-Acting Antiviral Therapy for Chronic Hepatitis C Virus Using Pretreatment Immunological Markers., Front Immunol. 2018 Feb 7; 9:146. doi: 10.3389/fimmu.2018.00146.
- Beckhove P., Targeting immune modulatory pathways in cancer., Clin Immunol. 2018 Jan; 186:32-33. doi: 10.1016/j.clim.2017.09.006.
- Schmitz-Winnenthal FH, Hohmann N, Schmidt T, Podola L, Friedrich T, Lubenau H, Springer M, Wieckowski S, Breiner KM, Mikus G, Büchler MW, Keller AV, Koc R, Springfeld C, Knebel P, Bucur M, Grenacher L, Haefeli WE, Beckhove P., A phase 1 trial extension to assess immunologic efficacy and safety of prime-boost vaccination with VXM01, an oral T cell vaccine against VEGFR2, in patients with advanced pancreatic cancer., Oncoimmunology. 2018 Jan 16; 7(4):e1303584. doi: 10.1080/2162402X.2017.1303584.
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